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Weighted gene co-expression network analysis (WGCNA) identified genotype-driven, rather than treatment-driven, gene modules, highlighting distinct transcriptional architectures between WT and KO animals

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Part of this may be due to its antioxidant properties, but the "why" behind this isnt fully understood

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Accessed on February 24, 2026 Seeking Alpha, Pfizer strikes $495M deal for obesity drug rights in China

This configuration supports receptor-level interaction within adipocytes while minimizing affinity for the growth hormone receptor, distinguishing it from full-length GH and preventing downstream IGF-1 pathway activation